KÜLKUF

Technology

What is ClimaCon®?

KÜLKUF, powered by the patented ClimaCon®  technology, incorporates a novel heat transport mechanism that regulates the body's core temperature.  It incorporates principles of the Peltier effect, embedding a thermoelectric unit with a geometrically optimized heat sink. This highly efficient thermoelectric unit, accompanied by a material with a high heat transfer coefficient, is the engine that drives ClimaCon.®

 

What happens to the body during a hot flash?

KULKUF menopause treatment

Thermoregulation is very important to our survival during extreme temperature events.  This regulatory process is under the control of the hypothalamus, a small structure located in the brain. The primary thermoregulators are vasodilation and sweating during times of excess heat while vasoconstriction and shivering are more active during periods of extreme cold.  Both the conservation and generation of heat are the cornerstones of this sophisticated system.

Although falling estrogen levels in the middle-aged female has been thought to be the primary precipitating factor in the symptoms of hot flashes, we now know that patients with some types of cancers as well as Fibromyalgia, Lupus and Multiple Sclerosis experience hot flashes. While core temperature changes necessary to produce the symptoms of hot flashes is rather wide in the non-menopausal female, the range becomes narrower in the menopausal female, which is thought to be the result of lower estrogen levels. As a result of this narrowing of the core temperature range, slight variations in the core temperature can produce a hot flash.  The frequency and severity of hot flashes is thought to be related to the narrowing of the core temperature.range.

If the core temperature becomes too high, the Hypothalamus sends a message of vasodilation and sweating and if too cold, the message is shivering and vasoconstriction.  During a hot flash, the hypothalamus senses a rise in the core temperature which triggers vasodilation and sweating, both of which reduce the core temperature. It is this vasodilation that produces the flush, red warm skin during a hot flash.  Once the core temperature has returned to normal, the hypothalamus sends a signal terminating the vasodilation and sweating until the next hot flash occurs.